Postdoctoral Fellow –Cardiac mitochondrial Ca2+ handling
Cardiovascular Research Center, Rhode Island Hospital, Brown University, Providence RI
Postdoctoral position is available in the laboratory of Dr. Jin O-Uchi at the Cardiovascular Research Center (CVRC), Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence RI (http://cvrc.brownmedicine.org/). My lab is seeking one highly motivated postdoctoral fellow with an interest in cardiac ion channel physiology and mitochondrial biology. Our research aims to explore the detailed mechanism underlying the cardiac excitation and contraction/metabolism coupling by Ca2+ ion in the normal and disease hearts. Specifically, we are investigating the significance of adrenergic signaling in heart and its regulation of cardiac ion channel/transporters.
The interdisciplinary CVRC is home to scientists, physician-scientists and students investigating molecular mechanisms of cardiac disease, with focal areas in cardiac hypertrophy and failure, ischemia/reperfusion, arrhythmias and sudden cardiac death. Investigators are supported by Hospital- and Brown-based core facilities.
Applicants will be expected to study the role of adrenergic signaling on mitochondrial Ca2+ influx mechanism in the normal and disease hearts using novel mitochondria-targeted biosensors for Ca2+, ATP, and ROS measurements. The candidate will have unique opportunities to carry out interdisciplinary researches, which cover cardiac physiology, molecular biology and ion channel biophysics to address biologically and clinically significant questions. Multidisciplinary techniques such as gene transfer, Western blot, patch clamping and confocal imaging are routinely applied to isolated cardiac mitochondria, single live cells, tissues, and in vivo preparations.
Candidates should have a PhD and/or MD degree and postdoctoral/predoctoral research training in cardiac physiology and/or mitochondrial biology. It is preferred that the applicants have experience in Ca2+ imaging, confocal microscopy, cardiac electrophysiology, and mitochondrial biology. Additional qualifications include excellent interpersonal and communication skills, including the ability to publish in English language peer-reviewed journals. The salary will be based on years of experience, commensurate with NIH guidelines
Interested candidates should submit curriculum vitae, a brief cover letter highlighting their career goals and major accomplishments as well as contact information of three references to: firstname.lastname@example.org. Electronic submission in pdf format is encouraged. Review of applications will commence immediately, and will continue until the position is filled. Rhode Island Hospital is an equal opportunity and affirmative action employer
Additional information for PI and O-Uchi lab is available at:
A Postdoctoral position in cardiac cellular electrophysiology is available at the Cardiovascular Research Center, Warren Alpert Medical School of Brown University.
Our cellular electrophysiology laboratories are studying cellular mechanisms of cardiac arrhythmias and sudden cardiac death in transgenic rabbits with long QT phenotype. Experience in patch clamp recordings of cardiac myocytes and analyses of cardiac cellular electrophysiology data are required.
Please email your cover letter, resume and three letters of recommendation to Gideon_Koren@Brown.edu.